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Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA.

Org Biomol Chem. 2009 Feb 21;7(4):635-8. doi:10.1039/b816495a. Epub 2008 Dec 19
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摘要

The efficient synthesis of a range of stable SAM mimetics, and their ability to promote the binding of the E. coli methionine repressor (MetJ) to its operator DNA, is described.

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