Utilization of the porcine system to study lymphotoxin-beta regulation in intestinal lymphoid tissue.
[No authors listed]
摘要
Lymphotoxin-beta (LT-beta) has been suggested to be a regulator of secondary lymphoid structure development. In the present study, we isolated porcine LT-beta (poLT-beta) from adult swine spleens. The open reading frame encoded a predicted 246-amino acid polypeptide exhibiting higher similarity to the human than the mouse LT-beta protein. Expression of LT-beta mRNA in various swine tissues was analyzed by real-time PCR, and it was found to be higher in the ileal Peyer's patches (Pps) of adults than in newborns. In addition, ligand stimulation of toll-like receptors 2, 4, and 9, which are activated by bacterial components, increased LT-beta expression only in neonatal ileal Pps. These results suggest that colonization by commensal bacteria may affect the maturation of neonatal ileal Pps by the induction of LT-beta via toll-like receptors. LT-beta may therefore be useful for studying the development of the intestinal immune system at parturition in both swine and humans.
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基因功能
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原始数据
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文献解读
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