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Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10.

J Biol Chem. 2009 Jan 02;284(1):363-371. Epub 2008 Nov 07
Ying-Hua Li 1 , Sharang Ghavampur 1 , Percy Bondallaz 1 , Lena Will 1 , Gabriele Grenningloh 1 , Andreas W Pu Schel 2
Ying-Hua Li 1 , Sharang Ghavampur 1 , Percy Bondallaz 1 , Lena Will 1 , Gabriele Grenningloh 1 , Andreas W Pu Schel 2
+ et al

[No authors listed]

Author information
  • 1 Abteilung Molekularbiologie, Institut fu¨r Allgemeine Zoologie und Genetik, Westfa¨lische Wilhelms-Universita¨t Mu¨nster, Schloßplatz 5, D-48149 Mu¨nster, Germany and the Center for Psychiatric Neuroscience, Department of Psychiatry-Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1008 Prilly, Switzerland.
  • 2 Abteilung Molekularbiologie, Institut fu¨r Allgemeine Zoologie und Genetik, Westfa¨lische Wilhelms-Universita¨t Mu¨nster, Schloßplatz 5, D-48149 Mu¨nster, Germany and the Center for Psychiatric Neuroscience, Department of Psychiatry-Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1008 Prilly, Switzerland. Electronic address: apuschel@uni-muenster.de.

摘要


The GTPase Rnd1 affects actin dynamics antagonistically to Rho and has been implicated in the regulation of neurite outgrowth, dendrite development, and axon guidance. Here we show that Rnd1 interacts with the microtubule regulator SCG10. This interaction requires a central domain of SCG10 comprising about 40 amino acids located within the N-terminal-half of a putative alpha-helical domain and is independent of phosphorylation at the four identified phosphorylation sites that regulate SCG10 activity. Rnd1 enhances the microtubule destabilizing activity of SCG10 and both proteins colocalize in neurons. Knockdown of Rnd1 or SCG10 by suppressed axon extension, indicating a critical role for both proteins during neuronal differentiation. Overexpression of Rnd1 in neurons induces the formation of multiple axons. The effect of Rnd1 on axon extension depends on SCG10. These results indicate that SCG10 acts as an effector downstream of Rnd1 to regulate axon extensions by modulating microtubule organization.