例如:"lncRNA", "apoptosis", "WRKY"

Preincision complex-I from the excision nuclease reaction among cochlear spiral limbus and outer hair cells.

J. Mol. Histol.2008 Dec;39(6):617-25. doi:10.1007/s10735-008-9202-1. Epub 2008 Nov 01
{{ author.authorName }}{{getOrganisationIndexOf(author)}} {{ author.authorName }}{{getOrganisationIndexOf(author)}}
{{ author.authorName }}{{getOrganisationIndexOf(author)}} {{ author.authorName }}{{getOrganisationIndexOf(author)}}
+ et al

[No authors listed]

Author information
  • {{index+1}} {{ organisation }}

摘要


The excision nuclease reaction defends the genome from endogenous and exogenous mutagens. The rate-limiting step in the reaction is facilitated by preincision complex-1 (PIC-1). PIC-1 is maintained by xeroderma pigmentosum A and C (XPA and XPC) through protein-protein interactions and DNA binding. XPA and XPC exhibit high-affinity for DNA adducts from the anticancer molecule, cisplatin. Systemic cisplatin treatment results in ubiquitous DNA adducts in the cochlea. Cochleae harvested from patients treated with cisplatin reveal dead outer hair cells among normal spiral limbus cells. Such discrepancy, suggest differences in genome defense repertoire among cochlear cells. The purpose of this study was to use cisplatin as a stimulus to examine XPA and XPC immunoreactivity among outer hair cells and spiral limbus cells. Fischer344 rats were treated with either one or two cycles of cisplatin, where each cycle lasted four days and separated by a 10 day rest period. Cochleae were harvested after each treatment cycle and four days after the second treatment cycle then processed for immunohistochemistry. Unlike spiral limbus cells, outer hair cells failed to acclimate to the cisplatin treatment cycles by regulating XPA and XPC immunoreactivity. These results imply that outer hair cells may have a limited capacity to mobilize PIC-I beyond basal demand.

KEYWORDS: {{ getKeywords(articleDetailText.words) }}

基因功能


  • {{$index+1}}.{{ gene }}

图表


原始数据


 保存测序数据
Sample name
Organism Experiment title Sample type Library instrument Attributes
{{attr}}
{{ dataList.sampleTitle }}
{{ dataList.organism }} {{ dataList.expermentTitle }} {{ dataList.sampleType }} {{ dataList.libraryInstrument }} {{ showAttributeName(index,attr,dataList.attributes) }}

文献解读