The expression of somatostatin receptors in the hippocampus of pilocarpine-induced rat epilepsy model.

During the course of this study, we sought examine whether the expression of somatostatin receptors is altered in the hippocampus following pilocarpine-induced status epilepticus (SE) in order to understand the role/function of in the hippocampus after epileptogenic insults. and immunoreactivities were increased in the hippocampus at 1 week after SE. At 4 weeks after SE, SRIF1-family 2A, and immunoreactivity was increased only in neuropil. Both and 2B immunoreactivities were increased in CA2-3 pyramidal cells. However, and duanyu1942R4 immunoreactivities were reduced in the CA1 pyramidal cells of epileptic rat due to neuronal loss. In addition, immunoreactivity was reduced in CA2 pyramidal cells and various interneurons. Both and duanyu1942R4 immunoreactivities were increased within microglia following SE. Our findings suggest that increases in neuron-glial expressions may be closely related to the enhanced inhibition of the dentate gyrus and regulation of reactive microgliosis in the hippocampus of a pilocarpine model of temporal lobe epilepsy.

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