例如:"lncRNA", "apoptosis", "WRKY"

Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice.

Viral Immunol.2008 Sep;21(3):341-6. doi:10.1089/vim.2008.0036
Misty R Jenkins 1 , Joseph A Trapani , Peter C Doherty , Stephen J Turner
Misty R Jenkins 1 , Joseph A Trapani , Peter C Doherty , Stephen J Turner

[No authors listed]

Author information
  • 1 Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia. mrj33@cam.ac.uk

摘要


Granzyme (grz) AB(-/-) H2(b) mice generate numerically normal cytotoxic T lymphocyte (CTL) responses to the prominent influenza A virus D(b) NP(366) and D(b) PA(224) epitopes and terminate the infectious process in the pneumonic lung with the same kinetics as the WT controls. Though grz B protein expression is fully compromised, there is only a partial effect on the level of CTL activity measured in a classical, short-term (51)Cr release assay. Single-cell polymerase chain reaction (PCR) analysis of both highly activated effector and "resting" memory CD8(+) T cells from influenza A virus-infected grzAB(-/-) mice showed a high prevalence of grzK mRNA(+) expression in tetramer (tet)(+) CTLs as was found in WT mice. However, a marked reduction in cytotoxicity present in the primary splenic CTLs of grzAB(-/-) mice correlated with decreased grzK expression, as measured by real-time PCR. This suggests that grzK plays an important role in CD8(+) T-cell cytotoxicity both in the presence and absence of grzA and B.