Different allelic distribution of a single SNP between sexes in humans.
Biochem. Genet.2008 Dec;46(11-12):733-6. doi:10.1007/s10528-008-9188-0. Epub 2008 Sep 06
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摘要
We searched for a difference in allele distribution between males and females of a single nucleotide polymorphism located in the human beta T-cell receptor, in 500 subjects (200 males and 300 females). Genotype analysis gave the following results: among the males, 114 (57%) were heterozygous for the T/C polymorphism, 52 (26%) were homozygous (T/T), and 34 (17%) were homozygous (C/C). Among the females, 142 (47.3%) were heterozygous, 73 (24.3%) were homozygous (T/T), and 85 (28.3%) were homozygous (C/C). The allele frequency was significantly different between sexes (chi2 = 8.799, P = 0.012).
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基因功能
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原始数据
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文献解读
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