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The role and regulation of Trxl, a cytosolic thioredoxin in Schizosaccharomyces pombe.

J. Microbiol.2008 Aug;46(4):408-14. doi:10.1007/s12275-008-0076-4. Epub 2008 Aug 31
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摘要


The genome of fission yeast Schizosaccharomyces pombe harbors two genes for thioredoxins, trx1(+) and trx2(+), which encode cytosolic and mitochondrial thioredoxins, respectively. The Deltatrx1 mutant was found sensitive to diverse external stressors such as various oxidants, heat, and salt, whereas Deltatrx2 mutant was not sensitive except to paraquat, a superoxide generator. Both Deltatrx1 and Deltatrx2 mutants were more resistant to diamide, a thiol-specific oxidant, than the wild type. The trx1(+) gene expression was induced by H(2)O(2) and menadione, being mediated through a stress-responsive transcription factor Papl. In Deltatrx1 cells, the basal expression of Pap1-regulated genes were elevated, suggesting a role for Trxl as a reducer for oxidized (activated) Papl. The Deltatrx1 mutant exhibited cysteine auxotrophy, which can be overcome by adding sulfite. This suggests that Trxl serves as a primary electron donor for 3'-phosphoadenosine-5'-phosphosulfate (PAPS) reductase and thus is an essential protein for sulfur assimilation in S. pombe. These results suggest that, in contrast to Trx2 whose role is more confined to mitochondrial functions, Trxl plays a major role in protecting S. pombe against various stressful conditions and enables proper sulfur metabolism.

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