The yeast checkpoint kinase Dun1 downregulates DIN7 in the absence of DNA damage.

Biosci. Biotechnol. Biochem.2008 Jun;72(6):1630-4. Epub 2008 Jun 07

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摘要

Yeast DIN7 is a DNA damage-inducible gene. Its expression is increased in the absence of Dun1, a DNA damage checkpoint kinase. We identified a DIN7 promoter region responsible for Dun1-mediated downregulation and found that DIN7 expression was not further increased in response to hydroxyurea in Deltadun1 cells. Thus DIN7 repression by Dun1 can be released upon DNA damage.

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The yeast checkpoint kinase Dun1 downregulates DIN7 in the absence of DNA damage.

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