Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia.

OBJECTIVES:The cell adhesion proteins protocadherins and cadherins, through their effects on guiding neurons during development, neuronal differentiation, and synaptogenesis, are feasible targets to consider in schizophrenia (SZ) and bipolar disorder (BD) pathogenesis. Thus, allelic variation occurring in protocadherin and cadherin encoding genes that map to regions of the genome targeted in SZ and BD linkage studies are particularly strong candidates to consider as underlying susceptibility factors. One such set of candidate genes is the 5q31-linked PCDH family. A polymorphic copy number variation in this locus, a 16.7-kb deletion affecting PCDH-alpha exons 8-10 (alpha 8-alpha 10 Delta), was analyzed in this study as a potential candidate variant in SZ and BD. METHODS:The frequency of the alpha 8-alpha 10 Delta variant was determined in a cohort of Caucasian patients with SZ from the United States and a cohort of patients with BD from the Czech Republic, and corresponding controls by amplifying DNA with deletion specific primers followed by gel electrophoresis. RESULTS:No significant difference was observed in the frequency of the alpha 8-alpha 10 Delta variant in patients with SZ or BD compared with their respective controls. CONCLUSION:Although the results of this study were negative, theoretical considerations and linkage studies suggest that the 5q31-linked PCDH family should be analyzed as a potential locus underlying SZ and BD susceptibility.

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