Twin ushers guide pili across the bacterial outer membrane.

Cell. 2008 May 16;133(4):574-6

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The chaperone/usher pathway is responsible for the assembly of adhesive pili on the surface of gram-negative pathogenic bacteria. In this issue, Remaut et al. (2008) present the crystal structure of the PapC usher translocation domain and images of the FimD usher bound to a pilus translocation intermediate. These new structures provide the first detailed view of a translocase in action.

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Twin ushers guide pili across the bacterial outer membrane.

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