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Arabidopsis SCARs function interchangeably to meet actin-related protein 2/3 activation thresholds during morphogenesis.

Plant Cell. 2008 Apr;20(4):995-1011. Epub 2008 Apr 18
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摘要


During polarized growth and tissue morphogenesis, cells must reorganize their cytoplasm and change shape in response to growth signals. Dynamic polymerization of actin filaments is one cellular component of polarized growth, and the actin-related protein 2/3 complex is an important actin filament nucleator in plants. alone is inactive, and the Arabidopsis thaliana WAVE complex translates Rho-family small GTPase signals into an duanyu372/3 activation response. The SCAR subunit of the WAVE complex is the primary activator of and plant and vertebrate SCARs are encoded by a small gene family. However, it is unclear if SCAR isoforms function interchangeably or if they have unique properties that customize WAVE complex functions. We used the Arabidopsis distorted group mutants and an integrated analysis of SCAR gene and protein functions to address this question directly. Genetic results indicate that each of the four SCARs functions in the context of the pathway and together they define the lone mechanism for duanyu372/3 activation. Genetic interactions among the scar mutants and transgene complementation studies show that the activators function interchangeably to meet the threshold for duanyu372/3 activation in the cell. Interestingly, double, triple, and quadruple mutant analyses indicate that individual SCAR genes vary in their relative importance depending on the cell type, tissue, or organ that is analyzed. Differences among SCARs in mRNA levels and the biochemical efficiency of duanyu372/3 activation may explain the functional contributions of individual genes.

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