Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol.
Genes Brain Behav.2008 Aug;7(6):669-76. Epub 2008 Apr 07
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摘要
The mechanisms by which ethanol induces changes in behavior are not well understood. Here, we show that Caenorhabditis elegans loss-of-function mutations in the synaptic vesicle-associated RAB-3 protein and its guanosine triphosphate exchange factor AEX-3 confer resistance to the acute locomotor effects of ethanol. Similarly, mice lacking one or both copies of Rab3A are resistant to the ataxic and sedative effects of ethanol, and Rab3A haploinsufficiency increases voluntary ethanol consumption. These data suggest a conserved role of RAB-3-/RAB3A-regulated neurotransmitter release in ethanol-related behaviors.
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基因功能
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原始数据
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文献解读
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