Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.

Nat Genet. 2008 Mar;40(3):281-3. Epub 2008 Feb 10

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We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.

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Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.

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