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Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components.

Genetics. 2007 Dec;177(4):2525-30
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摘要

Here, we report genetic interactions with mdf-1(gk2)/MAD1 in Caenorhabditis elegans. Nine are evolutionarily conserved or phenotypic "interologs" and two are novel enhancers, hcp-1 and bub-3. We show that HCP-1 and HCP-2, the two CENP-F-related proteins, recently implicated in the spindle assembly checkpoint (SAC) function, do not have identical functions, since but not enhances the lethality of the SAC mutants.

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