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FKF1 and GIGANTEA complex formation is required for day-length measurement in Arabidopsis.

Science. 2007 Oct 12;318(5848):261-5. Epub 2007 Sep 13
Mariko Sawa 1 , Dmitri A Nusinow , Steve A Kay , Takato Imaizumi
Mariko Sawa 1 , Dmitri A Nusinow , Steve A Kay , Takato Imaizumi

[No authors listed]

Author information
  • 1 Department of Biochemistry, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

摘要


Precise timing of CONSTANS (CO) gene expression is necessary for day-length discrimination for photoperiodic flowering. The FLAVIN-BINDING, KELCH REPEAT, F-BOX 1 (FKF1), and GIGANTEA (GI) proteins regulate CO transcription in Arabidopsis. We demonstrate that FKF1 and GI proteins form a complex in a blue-light-dependent manner. The timing of this interaction regulates the timing of daytime CO expression. FKF1 function is dependent on GI, which interacts with a CO repressor, CYCLING DOF FACTOR 1 (CDF1), and controls CDF1 stability. GI, FKF1, and CDF1 proteins associate with CO chromatin. Thus, the FKF1-GI complex forms on the CO promoter in late afternoon to regulate CO expression, providing a mechanistic view of how the coincidence of light with circadian timing regulates photoperiodic flowering.