Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity.
Org. Lett.2007 Sep 27;9(20):3877-80. doi:10.1021/ol0712677. Epub 2007 Sep 01
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摘要
Selective inactivation of cytosolic thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity was studied, which provides an example for rationally developing mechanism-based inhibitors based on a side activity of the enzyme, and may become a supplemental method for better treatment of cardiovascular disease and cancer.
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基因功能
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原始数据
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文献解读
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