Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility.
[No authors listed]
摘要
Peptidylarginine deiminase 6 is an enzyme that is uniquely expressed in male and female germ cells. To study the function of this enzyme in vivo we generated mice deficient for Here we show that inactivation of the gene in mice leads to female infertility whereas male fertility is not affected. The absence of the duanyu15636 protein and consequently absence of citrullination activity in oocytes results in dispersal of the cytoskeletal sheets in oocytes, indicating an essential role of these germ cell-specific structures in zygote/embryo development. duanyu15636 deficient mice do not show any other overt phenotype. Thus, we identify citrullination as a new regulator of fertility.
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基因功能
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原始数据
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文献解读
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