Substrate specificity of Escherichia coli thymidine phosphorylase.

Biochemistry Mosc.2007 Jan;72(1):21-8

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Substrate specificity of Escherichia coli thymidine phosphorylase to thymidine derivatives modified at 5' -, 3' -, and 2' ,3' - positions of the sugar moiety was studied. Equilibrium and kinetic constants (K(m), K(I), k(cat)) of the phosphorolysis reaction have been determined for 20 thymidine analogs. The results are compared with X-ray and molecular dynamics data. The most important hydrogen bonds in the enzyme-substrate complex are revealed.

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Substrate specificity of Escherichia coli thymidine phosphorylase.

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