The circling mouse (C57BL/6J-cir) has a 40-kilobase genomic deletion that includes the transmembrane inner ear (tmie) gene.

The circling mouse (C57BL6-cir) shows deafness and circling behavior in homozygotes. The mutation is transmitted with 100% penetrance by an autosomal recessive gene on chromosome 9. In the present study, we characterized the circling mutation as a 40-kilobase deletion that includes the transmembrane inner ear (tmie) gene. The tmie gene was first identified because its mutation causes deafness and circling behavior in spinner mice. We suggest that the genomic deletion of circling mice is a different, but allelic, mutation to that of spinner mice. In addition, during general behavioral investigations for complementation tests of the 2 strains, we found that circling and spinner mice may differ in their behavioral responses to a new environment.

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