YjjG, a dUMP phosphatase, is critical for thymine utilization by Escherichia coli K-12.

J. Bacteriol.2007 Mar;189(5):2186-9. Epub 2006 Dec 22

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摘要

Exogenous thymine must be converted to thymidine to enable a thyA (thymidylate synthase) mutant to grow. The deoxyribose in the thymidine comes from dUMP, which must first be dephosphorylated. The nucleotidase YjjG is critical for this step. A yjjG thyA mutant cannot use thymine for growth on a glucose minimal medium.

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YjjG, a dUMP phosphatase, is critical for thymine utilization by Escherichia coli K-12.

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