例如:"lncRNA", "apoptosis", "WRKY"

Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17.

FEBS Lett.2007 Jan 9;581(1):41-4. Epub 2006 Dec 06
Umut Sahin 1 , Carl P Blobel
Umut Sahin 1 , Carl P Blobel

[No authors listed]

Author information
  • 1 Arthritis and Tissue Degeneration Program, Caspary Research Building, Room 426, Hospital for Special Surgery, New York, NY 10021, USA.

摘要


All ligands of the epidermal growth factor receptor (EGFR), which has important roles in development and disease, are made as transmembrane precursors. Proteolytic processing by ADAMs (a disintegrin and metalloprotease) regulates the bioavailability of several EGFR-ligands, yet little is known about the enzyme responsible for processing the recently identified EGFR ligand, epigen. Here we show that ectodomain shedding of epigen requires ADAM17, which can be stimulated by phorbol esters, phosphatase inhibitors and calcium influx. These results suggest that ADAM17 might be a good target to block the release of bioactive epigen, a highly mitogenic ligand of the EGFR which has been implicated in wound healing and cancer.