Xlf1 is required for DNA repair by nonhomologous end joining in Schizosaccharomyces pombe.
Genetics. 2007 Feb;175(2):963-7. Epub 2006 Dec 06
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摘要
The accurate repair of DNA double-strand breaks is essential for cell survival and maintenance of genome integrity. Here we describe xlf1+, a gene in the fission yeast Schizosaccharomyces pombe that is required for repair of double-strand breaks by nonhomologous end joining during G1 phase of the cell cycle. Xlf1 is the ortholog of budding yeast Nej1 and human XLF/Cernunnos proteins.
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基因功能
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原始数据
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文献解读
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