Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain.
Nat. Struct. Mol. Biol.2006 Nov;13(11):1029-30. Epub 2006 Oct 22
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摘要
The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into vesicles that accumulate within multivesicular bodies (MVBs). Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. The structure suggests how human ESCRT-II can couple recognition of ubiquitinated cargoes and endosomal phospholipids during MVB protein sorting.
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基因功能
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原始数据
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文献解读
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