例如:"lncRNA", "apoptosis", "WRKY"

Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage.

Genes Dev.2006 Sep 15;20(18):2618-27
Ruth Grosskortenhaus 1 , Kristin J Robinson , Chris Q Doe
Ruth Grosskortenhaus 1 , Kristin J Robinson , Chris Q Doe

[No authors listed]

Author information
  • 1 Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA.

摘要


Embryonic development requires generating cell types at the right place (spatial patterning) and the right time (temporal patterning). Drosophila neuroblasts undergo stem cell-like divisions to generate an ordered sequence of neuronal progeny, making them an attractive system to study temporal patterning. Embryonic neuroblasts sequentially express Hunchback, Krüppel, Pdm1/Pdm2 (Pdm), and Castor (Cas) transcription factors. Hunchback and Krüppel specify early-born temporal identity, but the role of Pdm and Cas in specifying temporal identity has never been addressed. Here we show that Pdm and Cas regulate late-born motor neuron identity within the NB7-1 lineage: Pdm specifies fourth-born U4 motor neuron identity, while Pdm/Cas together specify fifth-born U5 motor neuron identity. We conclude that Pdm and Cas specify late-born neuronal identity; that Pdm and Cas act combinatorially to specify a temporal identity distinct from either protein alone, and that Cas repression of pdm expression regulates the generation of neuronal diversity.