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Dysfunction of paracellin-1 by dephosphorylation in Dahl salt-sensitive hypertensive rats.

J Physiol Sci. 2006 Oct;56(5):379-83. Epub 2006 Sep 09
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摘要


A high-salt diet reduced the levels of renal cAMP content and serine-phosphorylated paracellin-1 in Dahl salt-sensitive hypertensive rats. In MDCK cells expressing paracellin-1, protein kinase A inhibitor reduced the serine-phosphorylated paracellin-1 and transepithelial Mg(2+) transport, suggesting that a dephosphorylation of paracellin-1 induces the reduction of Mg(2+) reabsorption in salt-sensitive hypertension.

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