Mice naturally resistant to Yersinia pestis Delta pgm strains commonly used in pathogenicity studies.
Infect. Immun.2006 Nov;74(11):6501-4. Epub 2006 Sep 05
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摘要
We report that females of some substrains of inbred mouse strain 129 are resistant to systemic plague due to conditionally virulent Deltapgm strains of Yersinia pestis; however, fully virulent Y. pestis is not attenuated in these mice. Therefore, these mice offer a powerful system in which to map in parallel host resistance traits and opposing bacterial virulence properties for plague.
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文献解读
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