例如:"lncRNA", "apoptosis", "WRKY"

A global genomic transcriptional code associated with CNS-expressed genes.

Exp. Cell Res.2006 Oct 01;312(16):3108-19. Epub 2006 Jun 21
Peter J Bailey 1 , Joanna M Klos , Elisabet Andersson , Mattias Karlén , Magdalena Källström , Jasmina Ponjavic , Jonas Muhr , Boris Lenhard , Albin Sandelin , Johan Ericson
Peter J Bailey 1 , Joanna M Klos , Elisabet Andersson , Mattias Karlén , Magdalena Källström , Jasmina Ponjavic , Jonas Muhr , Boris Lenhard , Albin Sandelin , Johan Ericson
+ et al

[No authors listed]

Author information
  • 1 Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, S-171, 77 Stockholm, Sweden.

摘要


Highly conserved non-coding DNA regions (HCNR) occur frequently in vertebrate genomes, but their functional roles remain unclear. Here, we provide evidence that a large portion of HCNRs are enriched for binding sites for Sox, POU and Homeodomain transcription factors, and such HCNRs can act as cis-regulatory regions active in neural stem cells. Strikingly, these HCNRs are linked to several hundreds of genes expressed in the developing CNS and they may exert locus-wide regulatory effects on multiple genes flanking their genomic location. Moreover, these data imply a unifying transcriptional logic for a large set of CNS-expressed genes in which Sox and POU proteins act as generic promoters of transcription while Homeodomain proteins control the spatial expression of genes through active repression.