例如:"lncRNA", "apoptosis", "WRKY"

A functional network involved in the recycling of nucleocytoplasmic pre-60S factors.

J Cell Biol. 2006 May 08;173(3):349-60. Epub 2006 May 01
Alice Lebreton 1 , Cosmin Saveanu , Laurence Decourty , Jean-Christophe Rain , Alain Jacquier , Micheline Fromont-Racine
Alice Lebreton 1 , Cosmin Saveanu , Laurence Decourty , Jean-Christophe Rain , Alain Jacquier , Micheline Fromont-Racine
+ et al

[No authors listed]

Author information
  • 1 Génétique des Interactions Macromoléculaires, Centre National de la Recherche Scientifique URA2171, Institut Pasteur, 75724 Paris Cedex 15, France.

摘要


Eukaryotic pre-ribosomes go through cytoplasmic maturation steps before entering translation. The nucleocytoplasmic proteins participating in these late stages of maturation are reimported to the nucleus. In this study, we describe a functional network focused on Rei1/Ybr267w, a strictly cytoplasmic pre-60S factor indirectly involved in nuclear 27S pre-ribosomal RNA processing. In the absence of Rei1, the nuclear import of at least three other pre-60S factors is impaired. The accumulation in the cytoplasm of a small complex formed by the association of Arx1 with a novel factor, Alb1/Yjl122w, inhibits the release of the putative antiassociation factor Tif6 from the premature large ribosomal subunits and its recycling to the nucleus. We propose a model in which Rei1 is a key factor for the coordinated dissociation and recycling of the last pre-60S factors before newly synthesized large ribosomal subunits enter translation.