An allele of gyrA prevents Salmonella enterica serovar Typhimurium from using succinate as a carbon source.

J. Bacteriol.2006 Apr;188(8):3126-9

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摘要

A mutant gyrA allele resulting in an A271E substitution in the DNA gyrase protein generated a strain unable to grow on the C(4)-dicarboxylates succinate, malate, and fumarate. Bacteria harboring gyrA751 displayed decreased negative supercoiling in cells. Expression of the dctA gene, which encodes the C(4)-dicarboxylate transporter, was reduced in a gyrA751 mutant, providing the first evidence that dctA expression is supercoiling sensitive and uncovering a simple metabolic screen for lesions in gyrase that reduce negative supercoiling.

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An allele of gyrA prevents Salmonella enterica serovar Typhimurium from using succinate as a carbon source.

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