Aspartyl-tRNA synthetase is the target of peptide nucleotide antibiotic Microcin C.

J Biol Chem. 2006 Jun 30;281(26):18033-42. Epub 2006 Mar 30

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摘要

Microcin C is a ribosome-synthesized heptapeptide that contains a modified adenosine monophosphate covalently attached to the C-terminal aspartate. Microcin C is a potent inhibitor of bacterial cell growth. Based on the in vivo kinetics of inhibition of macromolecular synthesis, Microcin C targets translation, through a mechanism that remained undefined. Here, we show that Microcin C is a subject of specific degradation inside the sensitive cell. The product of degradation, a modified aspartyl-adenylate containing an N-acylphosphoramidate linkage, strongly inhibits translation by blocking the function of aspartyl-tRNA synthetase.

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Aspartyl-tRNA synthetase is the target of peptide nucleotide antibiotic Microcin C.

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