例如:"lncRNA", "apoptosis", "WRKY"

Aspartyl-tRNA synthetase is the target of peptide nucleotide antibiotic Microcin C.

J Biol Chem. 2006 Jun 30;281(26):18033-42. Epub 2006 Mar 30
Anastasia Metlitskaya 1 , Teymur Kazakov , Aigar Kommer , Olga Pavlova , Mette Praetorius-Ibba , Michael Ibba , Igor Krasheninnikov , Vyacheslav Kolb , Inessa Khmel , Konstantin Severinov
Anastasia Metlitskaya 1 , Teymur Kazakov , Aigar Kommer , Olga Pavlova , Mette Praetorius-Ibba , Michael Ibba , Igor Krasheninnikov , Vyacheslav Kolb , Inessa Khmel , Konstantin Severinov
+ et al

[No authors listed]

Author information
  • 1 Institute of Molecular Genetics, Russian Academy of Sciences, Moscow 123182, Russia.

摘要


Microcin C is a ribosome-synthesized heptapeptide that contains a modified adenosine monophosphate covalently attached to the C-terminal aspartate. Microcin C is a potent inhibitor of bacterial cell growth. Based on the in vivo kinetics of inhibition of macromolecular synthesis, Microcin C targets translation, through a mechanism that remained undefined. Here, we show that Microcin C is a subject of specific degradation inside the sensitive cell. The product of degradation, a modified aspartyl-adenylate containing an N-acylphosphoramidate linkage, strongly inhibits translation by blocking the function of aspartyl-tRNA synthetase.