Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-D-arabino heptulosonate 7-phosphate synthase.
Bioorg. Med. Chem. Lett.2006 Jun 1;16(11):2951-4. Epub 2006 Mar 24
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摘要
The first mechanism-based inhibitor of a 3-deoxy-D-arabino heptulosonate 7-phosphate (DAH7P) synthase has been synthesised in 12 steps from D-arabinose, and has been found to be a very slow binding inhibitor of Escherichia coli DAH7P synthase.
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基因功能
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原始数据
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文献解读
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