Mammalian mitochondrial nitric oxide synthase: characterization of a novel candidate.

FEBS Lett.2006 Jan 23;580(2):455-62. Epub 2005 Dec 20

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Recently a novel family of putative nitric oxide synthases, with AtNOS1, the plant member implicated in NO production, has been described. Here we present experimental evidence that a mammalian ortholog of AtNOS1 protein functions in the cellular context of mitochondria. The expression data suggest that a candidate for mammalian mitochondrial nitric oxide synthase contributes to multiple physiological processes during embryogenesis, which may include roles in liver haematopoesis and bone development.

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Mammalian mitochondrial nitric oxide synthase: characterization of a novel candidate.

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