Characterization of the DNA gyrase from the thermoacidophilic archaeon Thermoplasma acidophilum.
J. Bacteriol.2005 Dec;187(24):8531-6
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摘要
Thermoplasma acidophilum is sensitive to the antibiotic drug novobiocin, which inhibits DNA gyrase. We characterized DNA gyrases from T. acidophilum strains in vitro. The DNA gyrase from a novobiocin-resistant strain and an engineered mutant were less sensitive to novobiocin. The novobiocin-resistant gyrase genes might serve as T. acidophilum genetic markers.
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原始数据
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文献解读
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