[No authors listed]
The Caenorhabditis elegans basic leucine zipper (bZip) protein CES-2 regulates the transcription of different genes in different cells. Here, we show that CES-2 mediates its effects in one cell (the excretory duct cell) together with another bZip protein, ATF-2. Both proteins influence transactivation of a target gene, lin-48. Although lin-48 is required for both anatomical and physiological features of the excretory duct cell, ces-2 and atf-2 mutants only exhibit anatomical defects. We show that CES-2 and ATF-2 modify the temporal transcription of lin-48, acting to initiate embryonic expression required for normal excretory system development and anatomy. In contrast, CES-2 and ATF-2 do not influence post-embryonic lin-48 expression. We provide evidence that CES-2 and ATF-2 can interact with each other, and that they cooperate to form a complex on lin-48 regulatory sequences. Thus, the two bZip proteins function together as one of several inputs that influence the spatial and temporal regulation of lin-48.
KEYWORDS: {{ getKeywords(articleDetailText.words) }}
Sample name | Organism | Experiment title | Sample type | Library instrument | Attributes | |||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
{{attr}} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
{{ dataList.sampleTitle }} | {{ dataList.organism }} | {{ dataList.expermentTitle }} | {{ dataList.sampleType }} | {{ dataList.libraryInstrument }} | {{ showAttributeName(index,attr,dataList.attributes) }} |
{{ list.authorName }} {{ list.authorName }} |