The Kavar(D) dominant female-sterile mutations of Drosophila reveal a role for the maternally provided alpha-tubulin4 isoform in cleavage spindle maintenance and elongation.
Mol. Genet. Genomics. 2005 Jun;273(4):283-9. doi:10.1007/s00438-005-1109-x. Epub 2005 Apr 28
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摘要
The dominant-negative female-sterile Kavar(D) mutations and their revertant kavar(r) alleles identify the alphaTubulin67C gene of Drosophila melanogaster, which codes for the maternally provided alpha-tubulin(4) isoform. The mutations result in the formation of monopolar, collapsed spindles (each with two nearby centrosomes, a tassel of microtubules and overcondensed chromosomes), thus revealing a novel function for alpha-tubulin(4) in spindle maintenance and elongation. Molecular features of the two Kavar(D) alleles and a kavar(null) allele are described and models for their actions are discussed.
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基因功能
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原始数据
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文献解读
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