Induction of uteroglobin-related protein 2 (Ugrp2) expression by EGF and TGFalpha.
FEBS Lett.2005 Apr 11;579(10):2221-5
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摘要
Uteroglobin-related protein 2 (UGRP2) is thought to play a role in inflammation and/or epithelial cell differentiation in the lung. Induction of Ugrp2 mRNA expression by epidermal growth factor (EGF) and transforming growth factor alpha was examined using mouse transformed lung Clara cell-derived mtCC cells. The EGF-induced increase of Ugrp2 occurred at the transcriptional level that required the EGF receptor and the activation of the ERK-MAPK and phosphoinositide-3 kinase pathways.
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基因功能
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原始数据
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文献解读
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