C-terminus of p47(phox) is required for interaction with leukocyte type rat 12-lipoxygenase.

Protein Pept. Lett.2005 Apr;12(3):295-7. doi:10.2174/0929866053587066

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In yeast two-hybrid system, rat 12-lipoxygenase (12-LO) bound to complete (390 amino acids) or the N-terminus truncated form of human p47 (phox), but not to the C-terminus truncated form (residues 1-286). When glutathione S-transferase fused human p47(phox) was added to an in vitro 12-LO enzyme activity assay, formation of 12-hydroperoxyeicosatetraenoic acid was reduced significantly compared to the C-terminus truncated form. These results indicate that C-terminus of p47(phox) is important for its interaction to rat 12-LO.

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C-terminus of p47(phox) is required for interaction with leukocyte type rat 12-lipoxygenase.

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