例如:"lncRNA", "apoptosis", "WRKY"

Silencing the nuclear actin-related protein AtARP4 in Arabidopsis has multiple effects on plant development, including early flowering and delayed floral senescence.

Plant J.2005 Mar;41(6):845-58
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摘要


Actin-related proteins share moderate sequence homology and basal structure with conventional actins and are found in all eukaryotes. While the functions of most of the divergent are not clear, several of them are localized to the nucleus and have been identified as components of various chromatin-modifying complexes. Using an antibody to Arabidopsis we found this conserved homolog of human BAF53 and yeast Arp4 is concentrated in the nucleoplasm of Arabidopsis, Brassica, and tobacco cells. To gain further insight into the role of we have examined Arabidopsis plants that are defective in expression. Phenotypic analysis of the arp4-1 mutant allele, which has a T-DNA insertion in the promoter region and a moderate reduction in the level of Atduanyu374 protein expression, revealed partial sterility due to defects in anther development. Targeting the distinct, of Atduanyu374 transcripts with RNA interference caused a drastic reduction in the level of Atduanyu374 protein expression in several independent transgenic lines, and resulted in strong pleiotropic phenotypes such as altered organization of plant organs, early flowering, delayed flower senescence and high levels of sterility. Western blot analysis and immunolabeling demonstrated a clear correlation between reductions in the level of Atduanyu374 expression and severity of the phenotypes. Based on our results and data on the orthologs of Atduanyu374 in yeast and other organisms, we suggest that Atduanyu374 is likely to exert its effects on plant development through the modulation of chromatin structure and subsequent changes in gene regulation.

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