High expression during neurogenesis but not mammogenesis of a murine homologue of the Deleted in Breast Cancer2/Rhobtb2 tumor suppressor.
[No authors listed]
摘要
Deleted in Breast Cancer-2, Dbc2, identified as a candidate tumor suppressor gene for breast cancer and other human malignancies, is a member of a novel gene family encoding putative small GTPases designated as Rhobtb. In this report, we describe the spatio-temporal expression of mDbc2/Rhobtb2 mRNA during mammary gland development and embryogenesis in the mouse. We have first determined that mDbc2/Rhobtb2 transcripts are expressed at low, but seemingly constant levels during mammopoiesis. Secondly, we have found that mDbc2/Rhobtb2 is expressed highly and specifically in the central and peripheral nervous systems during mouse embryogenesis. While our results do not reveal any connection between elevated expression of mDbc2/Rhobtb2 and a specific stage of mammary gland development, they strongly support a role for this gene during development of the nervous system.
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基因功能
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原始数据
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文献解读
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