AF1q, a differentially expressed gene during neuronal differentiation, transforms HEK cells into neuron-like cells.

Brain Res. Mol. Brain Res.2004 Nov 24;131(1-2):126-30

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Three cell groups, neural stem/progenitor cells (NS/PCs) dissociated from the embryonic day 11 (E11) rodent cerebral cortex, expanded NS/PC cultures, and cultured neurons from E15, were used to conduct a genomic study with differential display (DD). The mouse Af1q, homologue of human AF1q, was found to be significantly up-regulated during the neuronal production from NS/PCs. The ectopic expression of human AF1q triggered the expression of the neuronal marker TuJ1 in non-neuronal human embryonic kidney (HEK) cells.

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AF1q, a differentially expressed gene during neuronal differentiation, transforms HEK cells into neuron-like cells.

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