Bombyx mori prothoracicostatic peptide inhibits ecdysteroidogenesis in vivo.

Arch. Insect Biochem. Physiol.2004 Aug;56(4):155-61. doi:10.1002/arch.20005

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Bombyx prothoracicostatic peptide (Bom-PTSP) is a brain neuropeptide that has recently been reported to have in vitro inhibitory activity to prothoracicotropic hormone ecdysteroid biosynthesis in the prothoracic gland of the silkworm, Bombyx mori. In the present report, Bom-PTSP has been shown to significantly decrease hemolymph ecdysteroid titer in the fifth instar larvae when Bom-PTSP was injected into the fifth instar day 8 silkworm larvae, resulting in significant delay in spinning behavior. This is the first evidence that Bom-PTSP inhibits in vivo ecdysteroidogenesis in the silkworm.

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Bombyx mori prothoracicostatic peptide inhibits ecdysteroidogenesis in vivo.

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