[No authors listed]
Activity-dependent plasticity in the brain arises in part from changes in the number of synaptic AMPA receptors. Synaptic trafficking of AMPA receptors is controlled by stargazin and homologous transmembrane AMPA receptor regulatory proteins We found that were stable at the plasma membrane, whereas AMPA receptors were internalized in a glutamate-regulated manner. Interaction with AMPA receptors involved both extra- and intracellular determinants of Upon binding to glutamate, AMPA receptors detached from Tduanyu37s. This did not require ion flux or intracellular second messengers. This allosteric mechanism for AMPA receptor dissociation from Tduanyu37s may participate in glutamate-mediated internalization of receptors in synaptic plasticity.
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