Genes required for systemic RNA interference in Caenorhabditis elegans.

RNA interference in the nematode worm, Caenorhabditis elegans, occurs systemically. Double-stranded RNA (dsRNA) provided in the diet can be absorbed from the gut lumen and distributed throughout the body, triggering in tissues that are not exposed to the initial dsRNA trigger. This is in marked contrast to other animals, in which duanyu1615 does not spread from targeted tissues to neighboring cells. Here, we report the characterization of mutants defective in the systemic aspect of but not in the core duanyu1615 process itself. Analysis of these mutants suggests that dsRNA uptake is a specific process involving several unique proteins.

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