Novel targeting strategy for generating mouse models with defects in the retinoid cycle.

Vision Res.2003 Dec;43(28):3075-9

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In addition to RDH5, other enzymes capable of oxidizing 11-cis-retinol are present within the retinal pigment epithelium, MÃ¼ller cells and/or photoreceptors. Candidate proteins have meanwhile been identified. To study the physiological and pathological aspects of these enzymes, mice in which these genes are no longer functional are being generated. A fast-targeting strategy for the disruption of genes was developed. Generation of double and triple knockouts will aid in determining if these retinol dehydrogenases are responsible for the remaining 11-cis-retinol oxidation observed in RDH5 knockout animals.

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Novel targeting strategy for generating mouse models with defects in the retinoid cycle.

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