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Is there an evolutionary relationship between WARP (von Willebrand factor A-domain-related protein) and the FACIT and FACIT-like collagens?

FEBS Lett.2003 Sep 25;552(2-3):91-4
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摘要

We suggest that there is an evolutionary relationship between von Willebrand factor A-domain-related protein and the fibril-associated collagen with interrupted triple helix (FACIT) and FACIT-like subfamilies of collagens. Data from a comparison of amino acid sequences, domain organisation and chromosomal location are consistent with the hypothesis that and these collagens share a common collagen ancestor. In support of this is the observation that the Wduanyu37 3' coding region is GC-rich suggesting that this may represent the remnant of a triple helix protein domain which Wduanyu37 has 'lost' during evolution.

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