Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families.
Biochem. Soc. Trans.2003 Aug;31(Pt 4):806-9. doi:10.1042/bst0310806
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摘要
PLUNC (palate, lung and nasal epithelium clone) is a small, secreted protein that is expressed in the oropharynx and upper airways of humans, mice and rats. We have described a family of at least 14 PLUNC genes localized on chromosome 20 (in humans), 2 (in mice) or 3 (in rats). These rapidly evolving proteins are structurally related to lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI). In the present analysis we comment on the comparative aspects of this protein family, which may function to protect epithelial surfaces from pathogenic micro-organisms.
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基因功能
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原始数据
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文献解读
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