Brain microvessel endothelin type A receptors are coupled to ceramide production.

Biochem. Biophys. Res. Commun.2003 Jun 20;306(1):282-5

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Treatment of brain microvessels with endothelin-1 evoked an early decrease in the sphingomyelin levels concomitantly with an increase in those of ceramides. These responses were time- and concentration-dependent. Evidence also shows that endothelin type A receptors are involved. This is the first report on the involvement of an agonist in the regulation of the ceramide signal transduction system on blood-brain barrier and shows a new pathway likely involved in the regulation of the cerebral microvascular functioning.

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Brain microvessel endothelin type A receptors are coupled to ceramide production.

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