A heme-deficient strain of Escherichia coli has a three-base pair deletion in a "hotspot" in hemA.

Biochim. Biophys. Acta. 2003 Apr 15;1626(1-3):102-5

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摘要

The key regulatory step in heme biosynthesis in Escherichia coli is at the level of glutamyl-tRNA reductase (GTR), an enzyme which is encoded by hemA. A strain, HU227, with a spontaneous in-frame mutation in hemA has no GTR activity. The mutation is shown to be a three-base deletion at a "hotspot" in the gene. The amino acid sequence in this region is highly conserved.

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A heme-deficient strain of Escherichia coli has a three-base pair deletion in a "hotspot" in hemA.

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