Molecular cloning and expression analysis of the mouse Spot-2 gene in pituitary development.
Dev. Genes Evol.2003 May;213(4):199-202. doi:10.1007/s00427-003-0313-0. Epub 2003 Apr 01
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摘要
Mouse Spot-1 is a DNA-binding protein with a domain (His-Thr) encoded by p(CA)n repeats. Spot-1 interacts with the nuclear localization signal (NLS) I of p53 through its His-Thr domain. In this study we describe the cloning and expression patterns of a novel gene encoding a protein containing a His-Thr domain, Spot-2. Spot-2 is exclusively expressed in the pituitary from stage E13.5 to E15.5. Mouse Lhx3 plays a critical role during early organogenesis in the pituitary. The Spot-2 gene appears to be a downstream gene of Lhx3. It is suggested that Spot-2 plays important roles in pituitary development.
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基因功能
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原始数据
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文献解读
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